1-st year of Medical Faculty

Academic year 2010/2011

2th semester (II)

- Responsible person:
Associated Professor Andrzej Hendrich

·  Lectures: 20 hours

·  Practicals: 30 hours

·  Seminars: 10 hours

Written exam at the end of the semester.

Lectures:

1. Prokaryotic and Eukaryotic cells, molecular components, structure of DNA.
2. Prokaryotic and Eukaryotic DNA replication.
3. Prokaryotic and Eukaryotic transcription and translation.
4. Regulation of gene expression.
5. Human genome, mitochondrial genome.
6. Cell cycle and its regulation.
7. Genetic basis of immune system.
8. DNA diversity, mutations, mutagenic factors: drugs, chemicals, physical, environmental, mechanisms of DNA repair.
9. Examples of gene related diseases.
10. Populational genetics.
11. Methods of molecular biology and their basic applications.
12. Pharmacogenetics.

Practicals:

Parasitology course content: diagnostic features, life cycles, symptoms of diseases caused by the human parasites, epidemiology, geographical distribution, diagnosis, prevention of human parasites.

I. Parasitilogy

1.   Flagellates: Trichomonas  vaginalis,  Giardia  intestinalis, Trypanosoma  brucei gambiense, Leishmania  tropica, L.  donovani 

 II. Parasitilogy

1.    Amoebae: Entamoeba  histolytica/dispar

2.    Apicomplexans: Plasmodium spp., Toxoplasma  gondii, Cryptosporidium parvum

III. Parasitilogy

1.   Colloquium – Protozoa

2.   Trematoda: Fasciola hepatica, Dicrocoelium  dendriticum, Schistosoma spp., Paragonimus westermani, Clonorchis sinensis

IV. Parasitilogy

1.    Cestoda: Diphyllobothrium  latum, Taenia  saginata, T.  solium, T. saginata asiatica, Hymenolepis nana, Echinococcus  granulosus, E.  multilocularis

V. Parasitilogy

1.   Nematoda: Ascaris  lumbricoides  hominis, Enterobius  vermicularis, Trichuris trichiura, Trichinella  spiralis, Loa loa, Strongyloides stercoralis

Seminars:

VI. Transmission Genetics

1.      Colloquium – Worms

2.      Mendelian genetics. Mendel’s Laws of inheritance (monohybrid, dihybrid crosses); test cross.

3.      Incomplete dominance, codominance, multiple alleles, lethal genes, gene interactions, pleiotropy.

VII. Transmission Genetics

1.   Human life cycle, mitosis and meiosis.

2.   Gametogenesis.

VIII. Transmission Genetics

1.   The Chromosome theory of heredity.

2.   Extrachromosomal inheritance.

IX. Transmission Genetics

1.   Sex determination.

2.   Lyon hypothesis.

X. Molecular Genetics

1. Colloquium – transmission genetics

         2. Nucleic acids – types and functions. The genetic code. Structure of the eukaryotic genome. Replication of DNA.

XI. Molecular Genetics

1.   Gene expression in prokaryotes and eukaryotes. The control of gene expression.

XII. Genetic Diseases     

1.   Colloquium – molecular genetics

2.   Inheritance of diseases caused by point mutations.

XIII. Genetic Diseases

1.   Inheritance of diseases caused by structural and numerical mutations.

XIV. Genetic Diseases

1. Colloquium – genetic diseases

References

1.    A. Cisowska, D. Tichaczek-Goska, M. Wesołowska, D. Wojnicz ”Medical biology for students faculty of medicine and faculty of dentistry” University of Medicine in Wrocław 2006, 2007, 2010

2.    W.S. Klug, Cummings M.R. “Genetics: a molecular perspective” Prentice Hall 2003

3.    Connor M., Ferguson-Smith M. “Essential medical genetics” Blackwell Science Ltd 1997

4.    B.J. Bogitsch, T.C. Cheng „Human parasitology“ Second edition, Academic Press 1998

5.  R. Muller “Worms and human disease” Second edition, CABI Publishing 2002